Vc1.1 (4) Protein Card

General Information

Name	Vc1.1
Organism	synthetic construct
Protein Type	Synthetic

Classification

Class	conotoxin
Gene superfamily
Cysteine framework	I [connectivity I-III, II-IV]
Pharmacological family	alpha conotoxin

Sequence

GCCSDPRCNYDHPEIC(nh2)
Modified residues	position symbol name 17 nh2 C-term amidation
Average Mass	1806.97
Monoisotopic Mass	1805.64
Isoelectric Point	4.80
Extinction Coefficient [280nm]	1490.00

References

Clark,R.J., Fischer,H., Nevin,S.T., Adams,D.J. and Craik,D.J. (2006) The synthesis, structural characterization, and receptor specificity of the alpha-conotoxin Vc1.1 J. Biol. Chem. 281:23254-23263

Sandall,D.W., Satkunanathan,N., Keays,D.A., Polidano,M.A., Liping,X., Pham,V., Down,J.G., Khalil,Z., Livett,B.G. and Gayler,K.R. (2003) A novel alpha-conotoxin identified by gene sequencing is active in suppressing the vascular response to selective stimulation of sensory nerves in vivo Biochemistry 42:6904-6911

Internal links

Nucleic acids
Structure	SOLUTION STRUCTURE OF ALPHA-CONOTOXIN VC1.1

External links

Ncbi

110590589

Tools

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Please cite: Kaas Q, Westermann JC, Halai R, Wang CK and Craik DJ. ConoServer, a database for conopeptide sequences and structures. Bioinformatics (2008) 24(3):445-6

ConoServer is managed at the Institute of Molecular Bioscience IMB, Brisbane, Australia.

Data and tools found on this website may be used for academic research only, provided that it is referred to ConoServer, the database of conotoxins (http://www.conoserver.org). For any other use please contact David Craik (d.craik@imb.uq.edu.au).

Contacts:
David Craik
Quentin Kaas

Last updated: Tuesday 24 November 2009