Welcome to ConoServer

Predatory marine cone snails use a diverse mixture of peptides known as conopeptides in the capture of their prey. A fascinating feature of these peptides is their high specificity and affinity towards human ion channels, receptors and transporters in the nervous system. This makes conopeptides an interesting resource in the research of neuroreceptors and promising drug leads. This site features a comprehensive repository of peptides isolated from the venom glands of snail from the Conus genus.

In order to track the vast number of different frameworks and novel peptide sequences that have been characterized this website presents a database of conotoxin peptide sequences and structures.

Conotoxin examples

Some examples of peptides from various cone snails (from left to right): ConKunitzin-S1 (C. striatus, pdb: 1y62), M1-type conotoxin MrIIIE (C. marmoreus, pdb: 2efz), ω-conotxin MVIIA (C. magus, pdb: 1ttk) and α-conotxin Vc1.1 (C.victoriae, pdb: 2h8s) .

Statistics Table (generated on Wednesday 14th of May 2008)

Number of Entries Species Coverage Links to UniProt, Genbank or PDB
Proteins 2261 67 2453
Nucleotides 1214 54 1214
Structures 99 23 99